Helminths were recovered from 12 (12%) of 100 deer mice (Peromyscus maniculatus) and 26 (24%) of 109 white-footed mice (P. leucopus) collected in 16 counties of southern Illinois. Helminths from deer mice included Choanotaenia peromysci (7.0%), Hymenolepis bennetti (2.0%), Postharmostomum helicis (1.0%), Physaloptera sp. (1.0%), Rictularia coloradensis (1.0%) and Moniliformis clarki (1.0%). Hymenolepis bennetti (1.8%), Physaloptera sp. (4.6%), and Rictularia coloradensis (20.0%) occurred in white-footed mice. C. peromysci and R. coloradensis revealed a high degree of host-specificity and along with Physaloptera showed some degree of habitat dependence. Infection rates were highest during the summer. Thirteen (65%) of 20 southern short-tailed shrews (Blarina carolinensis) were infected with Cryptocotylepis anthocephalus (40.0%), Brachylaima thompsoni (20.0%), Panopistus pricei (15.0%), Capillaria sp. (15.0%), Porrocaecum ensicaudatum (10.0%) and Porracaecum sp. (10.0%).