Sexual Dimorphism, Altered Hippocampal Glutamatergic Neurotransmission, and Cognitive Impairment in APP Knock-in Mice.

Authors

Caleigh A Findley, Southern Illinois University School of Medicine
Samuel A McFadden, Southern Illinois University School of Medicine
Tiarra Hill, Southern Illinois University School of Medicine
Mackenzie R Peck, Southern Illinois University School of Medicine
Kathleen Quinn, Southern Illinois University School of Medicine
Kevin N Hascup, Southern Illinois University School of Medicine
Erin R Hascup, Southern Illinois University School of Medicine

Abstract

BACKGROUND: It is well established that glutamatergic neurotransmission plays an essential role in learning and memory. Previous studies indicate that glutamate dynamics shift with Alzheimer's disease (AD) progression, contributing to negative cognitive outcomes.

OBJECTIVE: In this study, we characterized hippocampal glutamatergic signaling with age and disease progression in a knock-in mouse model of AD (APP

METHODS: At 2-4 and 18+ months old, male and female APP

RESULTS: Glutamate recordings support elevated stimulus-evoked glutamate release in the DG and CA3 of young APP

CONCLUSIONS: These findings confirm a sex-dependent hyper-to-hypoactivation glutamatergic paradigm in APP

Recommended Citation

Findley, Caleigh A, McFadden, Samuel A, Hill, Tiarra, Peck, Mackenzie R, Quinn, Kathleen, Hascup, Kevin N and Hascup, Erin R. "Sexual Dimorphism, Altered Hippocampal Glutamatergic Neurotransmission, and Cognitive Impairment in APP Knock-in Mice.." Journal of Alzheimer's disease : JAD 102, No. 2 (Nov 2024): 491-505. doi:10.3233/JAD-240795.