Date of Award


Degree Name

Doctor of Philosophy


Molecular Biology, Microbiology and Biochemistry

First Advisor

Cao, Deliang


Breast cancer is the most common type of cancer diagnosed among women in the United States, and the second cause of female cancer-related death, with approximately 40,000 deaths annually. Aldo-keto reductase 1B10 (AKR1B10) is a 35-kDa protein that is highly expressed in breast cancer in infiltrative and Ductal Carcinoma in Situ (DCIS) stages. Recent studies have demonstrated that AKR1B10 promotes breast cancer cell adhesion and invasion through the expression of integrin α5 and δ-catenin. Human epidermal growth factor receptor2 (HER2) is a tyrosine kinase receptor which is over expressed in over 60% of DCIS and in 15%-20% of infiltrative breast cancer, indicating decrease of HER2 positive tumors in the progression of DCIS to infiltrative cancer. The pathological overexpression of both AKR1B10 and HER2 in DCIS, combined with our knowledge about AKR1B10, leads us to hypothesized that AKR1B10 may promote HER2+ cell survival and proliferation through preventing anoikis.




This dissertation is only available for download to the SIUC community. Current SIUC affiliates may also access this paper off campus by searching Dissertations & Theses @ Southern Illinois University Carbondale from ProQuest. Others should contact the interlibrary loan department of your local library or contact ProQuest's Dissertation Express service.