Purpose: The purpose of this manuscript is to review the efficacy of antibiotic therapy in the treatment of acute uncomplicated appendicitis versus standard appendectomy.

Method: A PubMed literature search was conducted with keywords of acute appendicitis, antibiotics, and appendectomy. The publication date was limited to the last five years. Sample size less than 100 people, patient population less than five years of age, and articles examining only acute complicated appendicitis were excluded. Pertinent articles reviewing the efficacy of antibiotics compared to appendectomy serve as the basis for this clinical review.

Results: Antibiotic therapy alone could be a feasible intervention for most patients who wish to avoid surgical intervention.

Conclusion: While further investigation of non-operative management is ongoing, laparoscopic appendectomy continues to be the first-line treatment for acute uncomplicated appendicitis. Most patients with acute uncomplicated appendicitis should be offered a choice between non-operative management and antibiotics; however, there are still significant barriers to implementing this approach into routine care.