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Earlier studies have shown divergent results concerning the use of familiar picture stimuli in demonstration of equivalence. In the current experiment, we trained 16 children to form three 3-member classes in a many-to-one training structure. Half of the participants were exposed first to a condition with all abstract stimuli and then to a condition with new abstract stimuli as samples and 3 picture stimuli as comparisons (and nodes). The other participants were given the 2 conditions in the reverse order. The results, regardless of order, showed that the condition with picture stimuli as nodes was more effective in producing responding in accord with equivalence than stimulus sets with abstract stimuli only. In addition, more participants responded in accord with equivalence when they were trained with picture stimuli first. Reaction time to the comparison stimuli showed a greater increase with abstract stimuli than with pictures as nodes.