Two experiments paired a novel sucrose solution (conditioned stimulus, or CS) with injections of Ketaset-Rompun anesthesia (unconditioned stimulus, or US) to examine the effects of this anesthetic on the development of conditioned taste aversions (CTA) in Sprague-Dawley rats. Experiment 1 showed that using Ketaset-Rompun anesthesia as the US produced a reliable taste aversion, as rats injected with the anesthetic immediately after consumption of a novel sucrose solution drank significantly less sucrose on a 24-hr retention test compared to rats injected with an equivalent volume of saline at training. Additionally, Experiment 2 demonstrated that the level of Ketaset-Rompun-induced CTA varied with the CS-US interval. In this experiment, rats injected with the anesthetic demonstrated an aversion to sucrose at testing if the presentation of the CS was followed by injections of the US either immediately, 1 hr, or 2 hr later. However, when the US was administered 4 or 6 hr after presentation of the CS, no aversion to sucrose was manifested at testing. Furthermore, the results of Experiment 2 suggest that the largest CTA was obtained with the 2-hr delay condition. The methodological implications for researchers Ketaset-Rompun for surgical interventions is considered.
Metzger, Mitchell M.; Flint, Robert W. Jr.; and Riccio, David C.
"Ketaset-Rompun Anesthesia Induces a Conditioned Taste Aversion in Rats,"
The Psychological Record: Vol. 47
, Article 9.
Available at: https://opensiuc.lib.siu.edu/tpr/vol47/iss3/9