Date of Award
5-1-2017
Degree Name
Master of Science
Department
Chemistry
First Advisor
Hou, Yuqing
Abstract
Abstract A series of fluorescent promazine derivatives have been synthesized via Pechmann condensation reaction of (10-(3-(dimethylamino) propyl)-10H-phenothiazin-2-ol) with β-keto esters. It has been found that titanium (IV) chloride provided the best yield even at 10% of catalyst load, while other catalysts must be at 150-200% load to produce the desired products. For example, NbCl5 did not catalyze the reaction at 100% loading, but produced the desired product at 43% when the amount was increased to 150-200%. Strong complexation capacity of the promazine moiety may be responsible for the deactivation of the catalysts. The products are yellow-colored oil with very strong fluorescence.
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