Lifespan of Male and Female APP/PS1 and APPNL-F/NL-F Mouse Models of Alzheimer's Disease

Authors

Hannah Roberts, Southern Illinois University School of Medicine
Yimin Fang, Southern Illinois University School of Medicine
Kathleen Quinn, Southern Illinois University School of Medicine
Tiarra Hill, Southern Illinois University School of Medicine
Mackenzie R Peck, Southern Illinois University School of Medicine
Andrzej Bartke, Southern Illinois University School of Medicine
Kevin N Hascup, Southern Illinois University School of Medicine
Erin R Hascup, Southern Illinois University School of Medicine

Abstract

Alzheimer's disease (AD) disproportionately affects women, yet most preclinical research studies are male-centric. We performed lifespan analyses of male and female AD mouse models (APP/PS1 and APP^NL-F/NL-F) and their shared genetic background control (C57BL/6). Survival curves support significant sex differences between genotypes. Minimal longevity revealed increased age in male APP/PS1, and decreased age in male APP^NL-F/NL-F mice. Maximal longevity revealed an increased average age in males. Furthermore, median lifespan differed between sex and genotype. This study supports dimorphic survival in two mouse models of AD, emphasizing the need to examine mechanisms and treatments in both sexes.

Recommended Citation

Roberts, Hannah, Fang, Yimin, Quinn, Kathleen, Hill, Tiarra, Peck, Mackenzie R, Bartke, Andrzej, Hascup, Kevin N and Hascup, Erin R. "Lifespan of Male and Female APP/PS1 and APPNL-F/NL-F Mouse Models of Alzheimer's Disease." Journal of Alzheimer's disease : JAD 105, No. 1 (Mar 2025): 56-61. doi:10.1177/13872877251325878.