Studies on Hepatoprotective Properties of Leaf Extracts of Azadirachta indica A. Juss (Meliaceae)

Authors

T. Kalaivani, VIT University, Vellore
E. Meignanam, VIT University, Vellore
N. Premkumar, VIT University, Vellore
R. Siva, VIT University, Vellore
V. Vijayakumar, VIT University, Vellore
C. Rajasekaran, VIT University, Vellore
S. Ramya, VIT University, Vellore
R. Jayakumararaj, Raja Doraisingam Government Arts College, Sivagangai

Abstract

The present study was carried out to evaluate the hepatoprotective role of leaf extracts of Azadirachta indica A. Juss. Hepatoprotective activities of ethanolic and aqueous extracts of A. indica were examined against carbon tetrachloride induced liver damage in mice using silymarin as control. Enzyme activities of Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT) and Alkaline Phosphatase (ALP) were analyzed. Phytochemical leaf extracts of A. indica exhibited significant hepatoprotective activity. Ethanolic and aqueous leaf extracts of A. indica exhibited moderate activity over carbon tetrachloride treated animals. Results confirm the traditional - ethnomedicinal use of A. indica as a potential source of hepatoprotective agent.

Recommended Citation

Kalaivani, T.; Meignanam, E.; Premkumar, N.; Siva, R.; Vijayakumar, V.; Rajasekaran, C.; Ramya, S.; and Jayakumararaj, R. (2009) "Studies on Hepatoprotective Properties of Leaf Extracts of Azadirachta indica A. Juss (Meliaceae)," Ethnobotanical Leaflets: Vol. 2009: Iss. 1, Article 20.
Available at: https://opensiuc.lib.siu.edu/ebl/vol2009/iss1/20