Date of Award


Degree Name

Doctor of Philosophy



First Advisor

Elble, Randolph


Head and neck squamous cell carcinoma (HNSCC) develops in mucous membranes that line the mouth, throat and sinuses. It is the sixth most common cancer worldwide with more than 600,000 new cases diagnosed every year. The 5 year survival of HNSCC patients is less than 50% after initial diagnosis, while median survival after relapse or metastasis is less than one year. Unfortunately, the prognosis of HNSCC has not changed in the last two decades, mostly due to the poor understanding of the mechanism of this disease. New therapeutic targets and agents are in urgent need.

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