The noradrenergic system of the locus coeruleus has been implicated in a variety of processes including reinforcement, attention, and acquisition and retention of learned behaviors. Its dense projections, some of which are shared by the cholinergic system, provide an ideal network within which to study the cognitive impairments related to aging. The current investigation explored the effects of piperoxane, an
Compton, David M.; Dietrich, Kerri L.; and Smith, Jeffrey S.
"Enhancement of Spatial Navigation Ability in Older Rats Following Chronic Administration of the Alpha2 Noradrenergic Antagonist Piperoxane,"
The Psychological Record: Vol. 47
, Article 10.
Available at: http://opensiuc.lib.siu.edu/tpr/vol47/iss2/10