Date of Award


Degree Name

Master of Science



First Advisor

Kinsel, Gary


AN ABSTRACT OF THE THESIS OF Elizabeth Schroedl, for the Master of Science degree in Chemistry, presented on June 26, 2017, at Southern Illinois University Carbondale. TITLE: DETERMINATION OF VETERINARY ANTIBIOTICS VIA POLAR ORGANIC COMPOUND INTEGRATD SAMPLING (POCIS) MAJOR PROFESSOR: Dr. Gary Kinsel A growing concern in the environment is the occurrence of antibiotics in our water systems. Antibiotics are used extensively in veterinary practices on mass production animal farms. The primary mode of transport of antibiotics into the water systems is waste-water runoff from animal lots and agricultural fields. Passive sampling systems can be deployed to monitor the amount of antibiotics entering the water systems. This paper compares the use of a commercially available passive sampling device to a home-built device using Oasis HLB sorbent disks in order to validate a less expensive method of monitoring antibiotics in water systems. The home-built device was exposed to water spiked with various concentrations of antibiotics lincomycin and oxytetracycline over a period of 10 days. Disks were extracted and sampled at days 3, 7 and 10 using LCMS detection. The mean (n=9) result for lincomycin percent recovery using HLB disks was 86% with a sampling rate of 0.02550 mL/day and 62% for oxytetracycline with a sampling rate of 0.01745 mL/day. The commercial device was exposed to various concentrations of the antibiotics for 7 days. The mean (n=3) percent recovery for lincomycin was 104% with sampling rate of 0.03204 mL/day, and 74% for oxytetracycline with a sampling rate of 0.02262 mL/day. Results between days were inconsistent; however both devices followed the same trend at each concentration. With additional investigation, the home-build device is a valid alternative to the commercially available device for monitoring antibiotics in water systems.




This thesis is only available for download to the SIUC community. Others should
contact the interlibrary loan department of your local library.