Aerial parts of Eclipta alba are used traditionally for the treatment of several diseases of liver, skin and stomach. Methanolic extract and active principle compound of a well known Indian hepatoprotective herb, Eclipta alba was tested for in vitro antimicrobial studies. It was evaluated using zone of inhibition studies and minimum inhibitory concentration. The extract exhibited activity against all six strains studied. Phytochemical screening of the extract revealed the presence of tannins, flavonoids, coumestans, saponins and alkaloids etc. Ethylacetate fraction and further pure isolated wedelolactone showed enhanced antimicrobial activity. Staphylococcus epidermidis, Staphylococcus aureus and Salmonella typhimurium were most susceptible. Shigella flexneri was the most resistant bacterial strain. These results suggest coumestans/wedelolactone as a promising antimicrobial agent.
Dalal, Sunita; Kataria, Sudhir K.; Sastry, K. V.; and Rana, SVS
"Phytochemical Screening of Methanolic Extract and Antibacterial Activity of Active Principles of Hepatoprotective Herb, Eclipta alba,"
3, Article 3.
Available at: http://opensiuc.lib.siu.edu/ebl/vol2010/iss3/3