The study was carried out to investigate the central nervous system activity of Treculia africana. The central nervous system depressant properties of Treculia africana were determined using: Novelty –Induced Rearing and Grooming, Locomotor activity, Ketamine-induced sleeping time and effect on rectal body temperature. The crude extract produced decrease in rearing, grooming and locomotor activity. It also potentiated ketamineinduced sleeping time and produced hypothermic effect in mice. The crude extract possessed sedative effect, which may be through increase in the activity of GABA in the brain.
Aderibigbe, A. O.; Adeyemi, I. O.; and Agboola, O. I.
"Central Nervous System Depressant Properties of Treculia africana Decne,"
Ethnobotanical Leaflets: Vol. 2010
, Article 1.
Available at: http://opensiuc.lib.siu.edu/ebl/vol2010/iss2/1