Berberis lycium Royle (B.l.R) commonly known as Ishkeen (Kashmal and Darbald) is widely used in folk medicines for the treatment of Diabetes mellitus. Experimental diabetes use to alter the lipid profile. The aim of the present study was to evaluate the effects of Berberis lycium root bark on various lipid profiles in alloxan induced diabetic rabbits. Diabetes was induced by single intravenous injection of Alloxan (150 mg/kg).Oral administration of 250mg/kg and 500mg/kg crude powder of Berberis lycium root for four weeks resulted in significant reduction in total cholesterol, triglyceride and low density lipids (LDLs) levels. Berberis lycium treatment increased the levels of high density lipids (HDLs). Furthermore same doses stabilized the weight of diabetic rabbits. Thus our investigation clearly shows that crude powder of Berberis lycium Royle has antihyperlipidemic effect.
Ahmed, Maqsood; Alamgeer, Alamgeer; Sharif, Tanveer; Zabta CH, Muhammad; and Akbar, Atif
"Effect of Berberis lycium Royle on Lipid Profile in Alloxan Induced Diabetic Rabbits,"
6, Article 4.
Available at: http://opensiuc.lib.siu.edu/ebl/vol2009/iss6/4