The effect of Vitex trifolia Linn. (FamilyVerbenaceae) leaf extract was studied for the anti-nociceptive and anti-inflammatory activity in experimental animals. V. trifolia, 25 – 100 mg/kg administered orally for 3 days exhibited graded dose response equivalent to 21.95% - 89.90% protection in the tail flick latent test in rat. The V. trifolia leaf extract (50 and 100 mg/kg, p.o X 3 days) was effective in hot plate reaction time (64.05% and 112.97%, p< 0.01 and p< 0.001), analgesymeter induced mechanical pain (28.17% and 54.42%, p < 0.01 and p < 0.001) and acetic acid- induced writhing (26.68% and 51.79%, p < 0.5 and p < 0.05) in mice. The leaf extract of V. trifolia potentiated the analgesic activity with pentazocine (10 mg/kg, i.p.) and aspirin (25 mg/kg, i.p.). In the carrageenan- induced paw edema V. trifolia leaf extract (50 and 100 mg/kg, p.o X 3 days) decreased paw volume significantly (26.68% and 51.79%) and dose dependent anti-inflammatory activity in 1-3 hour time interval and potentiated with nimesulide (50 mg/kg, p.o.). In summary, this study demonstrates that leaf extract of V. trifolia has significant anti-nociceptive and anti-inflammatory activity.
Goverdhan, P. and Bobbala, Diwakar
"Anti-nociceptive and Anti-inflammatory Effects of the Leaf Extract of Vitex trifolia Linn. in Experimental Animals,"
1, Article 8.
Available at: http://opensiuc.lib.siu.edu/ebl/vol2009/iss1/8