Coccinia grandis (L.) Voigt (Cucurbitaceae), occurs throughout the world and has intensive popular use in the treatment of infections. The main aim of the present work was to investigate the antidiabetic effects of aqueous extracts of leaves of C. grandis obtained by Decoction method. Graded doses of the aqueous extract were administered to normal and experimental diabetic rats for 10 days. Significant (p < 0.05) reduction in fasting blood glucose levels were observed in the normal as well as in the treated diabetic animals. Serum insulin levels were not stimulated in the animals treated with the extract. The changes in body weight, serum lipid profiles, liver glycogen levels were assessed in the extract treated diabetic rats and compared with diabetic control and normal animals.
Doss, Asirvatham and Dhanabalan, Rangasamy
"Anti-hyperglycaemic and Insulin Release Effects of Coccinia grandis (L.) Voigt Leaves in Normal and Alloxan Diabetic Rats,"
Ethnobotanical Leaflets: Vol. 2008
, Article 155.
Available at: http://opensiuc.lib.siu.edu/ebl/vol2008/iss1/155