Publications

Anatomy of Motor Axons to Direct Flight Muscles in Drosophila

David G. King et al. — Thu, 23 Sep 2010 12:44:15 PDT

The direct flight muscles of Drosophila melanogaster are innervated by the anterior dorsal mesothoracic (ADM) nerve and the mesothoracic accessory (MAC) nerve. Each of the four conspicuously large axons in the ADM nerve serves one of the muscles designated pal, pa3, pa4 and pa5. Muscle pa4 is additionally innervated by a very small neurosecretory axon. Muscle pa6, also innervated by the ADM nerve, receives at least one small nerve fibre but no large axon. Muscle pa2 is innervated by a large axon from the MAC nerve. Large motor axons, identified by serial section tracing from their respective muscles, are consistent among different individuals in both relative positions and relative diameters within the ADM nerve.

Giant Fibre Activation of Direct Flight Muscles in Drosophila

Mark A. Tanouye et al. — Thu, 23 Sep 2010 12:44:15 PDT

Heretical DNA sequences?

David G. King et al. — Thu, 23 Sep 2010 12:33:21 PDT

Mutability and Evolvability: Indirect Selection for Mutability

David G. King et al. — Thu, 23 Sep 2010 12:33:21 PDT

Mutation Rate Variation in Eukaryotes: Evolutionary Implications of Site-specific Mechanisms

David G. King et al. — Thu, 23 Sep 2010 12:33:20 PDT

Simple Sequence Repeats as Advantageous Mutators in Evolution

Yechezkel Kashi et al. — Thu, 23 Sep 2010 12:33:20 PDT

Simple sequence repeats (SSRs) often serve to modify genes with which they are associated. The influence of SSRs on gene regulation, transcription and protein function typically depends on the number of repeats, while mutations that add or subtract repeat units are both frequent and reversible. SSRs thus provide a prolific source of quantitative and qualitative variation. Over the past decade, researchers have found that this spontaneous variation has been tapped by natural and artificial selection to adjust almost every aspect of gene function. These studies support the hypothesis that SSRs, by virtue of their special mutational and functional qualities, have a major role in generating the genetic variation underlying adaptive evolution.